ionary War's shifting into South Carolina, twenty-seven George Street served as the townhouse for the Barksdale Family when they were not at their country residence, Youghall Plantation.

The Barksdale family was very active in the thriving city life of Charleston. George Barksdale served a term in office as a tax inquirer and collector for his home parish, as well as a trustee of the Independent Church or Christ Church.

In May of 1817, George's nephew and them owner, Thomas Barksdale sold the townhouse. From that time on the house had numerous owners and occupants. The 1980's found the house unoccupied and in a state of disrepair until its meticulous restoration in 1985.